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Functional cholestasis can occur if drugs, hormones, cytokines, endotoxins or excess free fatty acids fatty acid toxicity interfere with the hepatocyte transporters, responsible for bilirubin excretion MRP2. Alterations in hepatocyte transporters are thought to be the primary events in mediating hepatocellular cholestasis.

Some transporters are present on cholangiocytes, although there is little known of these at present e. Uptake on sinusoidal or basolateral membrane from blood. The following transporters are located on the blood sinusoidal or basolateral aspect of hepatocytes and take up substances from blood into hepatocytes.


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Bile formation and flow is largely driven by excretion of bile salts, which are osmotically active and create a concentration gradient, which water follows allowing excretion of fluidic bile called bile salt-dependent flow. The latter exchanger is also found in cholangiocytes.

Laboratory diagnosis

Unconjugated bile salts, such as ursodeoxycholate which is used to treat some cholestatic conditions promote bile salt-dependent flow through stimulating this transporter. The active excretion of compounds into the biliary canaliculi is the rate limiting step for bile formation. Alterations in hepatocyte transporters are thought to be the primary events in mediating hepatocellular cholestasis.

Some transporters are present on cholangiocytes, although there is little known of these at present e.

Cholestasis

Uptake on sinusoidal or basolateral membrane from blood. The following transporters are located on the blood sinusoidal or basolateral aspect of hepatocytes and take up substances from blood into hepatocytes. Bile formation and flow is largely driven by excretion of bile salts, which are osmotically active and create a concentration gradient, which water follows allowing excretion of fluidic bile called bile salt-dependent flow. The latter exchanger is also found in cholangiocytes.


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  5. Unconjugated bile salts, such as ursodeoxycholate which is used to treat some cholestatic conditions promote bile salt-dependent flow through stimulating this transporter. The active excretion of compounds into the biliary canaliculi is the rate limiting step for bile formation. Excretion is accomplished by the following ATP-dependent transporters, which unlike some sinusoidal transporters, only work one way that is excretion of solutes into bile and not vice versa.


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