A whole skeletal muscle is considered an organ of the muscular system. Each organ or muscle consists of skeletal muscle tissue , connective tissue , nerve tissue , and blood or vascular tissue. Skeletal muscles vary considerably in size, shape, and arrangement of fibers. They range from extremely tiny strands such as the stapedium muscle of the middle ear to large masses such as the muscles of the thigh. Some skeletal muscles are broad in shape and some narrow.
In some muscles the fibers are parallel to the long axis of the muscle; in some they converge to a narrow attachment; and in some they are oblique. Each skeletal muscle fiber is a single cylindrical muscle cell. An individual skeletal muscle may be made up of hundreds, or even thousands, of muscle fibers bundled together and wrapped in a connective tissue covering.
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Each muscle is surrounded by a connective tissue sheath called the epimysium. Fascia , connective tissue outside the epimysium, surrounds and separates the muscles. Portions of the epimysium project inward to divide the muscle into compartments. Each compartment contains a bundle of muscle fibers.
Each bundle of muscle fiber is called a fasciculus and is surrounded by a layer of connective tissue called the perimysium. Concentration information loading The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Associated products. Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination.
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The phenotype at histological level is variable. Some patients present areas devoid of oxidative activity containg cores within myofibers. Core lesions are unstructured and poorly circumscribed.
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A congenital muscular disorder characterized at histological level by areas of sarcoplasm devoid of normal myofibrils and mitochondria, and replaced with dense masses of thin filaments. Central cores, rods, ragged red fibers, and necrosis are absent. CFTD is a genetically heterogeneous disorder in which there is relative hypotrophy of type 1 muscle fibers compared to type 2 fibers on skeletal muscle biopsy.
However, these findings are not specific and can be found in many different myopathic and neuropathic conditions. Datasheets and documents. CD5L is a pleiotropic player in liver fibrosis controlling damage, fibrosis and immune cell content. EBioMedicine 43 Am J Pathol Submit a review Submit a question.
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Abreviews Abreviews. Read More. Abcam user community Verified customer Submitted May 27 Get resources and offers direct to your inbox Sign up. Detects a band of approximately 45 kDa predicted molecular weight: 42 kDa.
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- Skeletal Muscle – Anatomy and Physiology;