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It very rarely occurs in any disorders other than narcolepsy type 1, so if it occurs it is very useful for diagnosis. In all three disorders idiopathic hypersomnia and both types of narcolepsy , patients fall asleep in less than 8 minutes on average. Idiopathic hypersomnia patients frequently, but not always, sleep for very long amounts of time.

Patients with idiopathic hypersomnia can be diagnosed with sleep testing that documents at least 11 hours of sleep per hour period. Some patients with narcolepsy, especially type 2, may also sleep long durations, but this is not considered part of the diagnostic criteria. Other clinical features, e. This chart summarizes the typical pattern of symptoms by diagnosis, based on review of the medical literature and clinical experience.

However, because many of these symptoms occur in more than one disorder, most are not part of the official diagnostic criteria for each disorder, and not every patient with a particular diagnosis will have this pattern of symptoms. Despite classification rules, some people end up getting diagnosed with both NT2 and IH during the course of their disease. People with NT1 made up their own cluster, as did people with IH with long sleep times. That is, the computer could reliably tell the difference between NT1 and IH with long sleep time, but could not distinguish those with NT2 from those with IH without long sleep time.

As the above discussion shows, different primary hypersomnia syndromes sometimes have overlapping clinical features because they were defined before the underlying causes were known. In practice, it can be helpful to cluster hypersomnia syndromes by underlying cause when it is known.

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In particular, if levels of hypocretin are low, it confirms the diagnosis of narcolepsy type 1, because this type of narcolepsy is known to be caused by an attack, likely auto-immune, on the hypocretin-producing nerve cells in a part of the brain known as the hypothalamus. Epub Oct Dauvilliers Y, Buguet A.

Dialogues Clin Neurosci. Th first one clearly said i had narcolepsy. A side thing is that my apnea wakes me most mornings after around 6. Where do they get this? I have no sleep interruptions. I sleep usually hrs. THAT is not the same thing. I finally was given a daytime sleep study and found to have Idiopathic Hypersomnia.

Maybe you would benefit from MSLT too. Hi, Can anybody help me. I am 50 years old and have suffered with chronic sleepiness for 24years. I am currently awaiting the results of a sleep study.

Symptoms (See Table)

I have previously been diagnosed with chronic fatigue syndrome but my symptoms just do not fit this diagnosis. I set 4 alarms each morning and manage to sleep through all of them. My partner struggles to wake me. If he wakes me and leaves the room, I go back to sleep and have no recollection of him waking me when I finally wake up. I never, ever have a refreshing sleep, even daytime naps leave me very sleepy. It is a constant battle to stay awake. I have worked full time up until 6 months ago. Even though this was a struggle, it gave me a regular routine to work to. Now I am self employed beautician and only have to leave the house at certain times, I am finding the urge to sleep overwhelming.

The problem is, if I give into this and nap, I usually sleep for about 4 hours. My brain feels Woolley all the time. My memory is appalling, my concentration is terrible. I find it difficult to follow written instructions. I yawn constantly throughout the day in excess of times.

I think I may have idiopathic hypersomnia but I may have to speak with my consultant over my concerns..

Symptomatic Narcolepsy or Hypersomnia, with and Without Hypocretin (Orexin) Deficiency

But I just wanted you to know that my heart goes out to you, and you are not alone sweetie. Hi Amanda, Yes, this was what I was like too. After many years of being told its depression, or being a working mom, or everyone is tired, or I need to eat better, excercise more so on and so on, my daytime sleep study showed how tired I am. I slept at every nap after the nighttime sleep study showed I slept fine and fell asleep within 2 mins at each nap. I have recently been diagnosed with IH.

Reading about your symptoms was like reading someone writing about my life. I was misdiagnose with Narcolepsy and now they are telling me I have Idiopathic Hyperinsomnia. I am so so exhausted and my doctor said I have depression, any help here, please. I had tried Clarithromycin without the end result i had prayed for. Idk if this helps… Take care. Its an enzyme deficiency in GABA degradation. Succinic semialdehyde accumulates and cannot be oxidized to succinic acid and is therefore reduced to GHB think of someone being roofied and date rape type sedation..

Therefore Kasha is correct in saying that testing positive for GABA A hyperactivity does not confirm you have the medical disorder Idiopathic Hypersomnia, at best it confirms you have Hypersomnia. There needs to be multiple studies from different institutions and input from the AASM on the topic. Rye, D. Bliwise, K. Parker, L. Trotti, P.

Narcolepsy | Stanford Health Care

Saini, J. Fairley, A. Freeman, P. Garcia, M.

What is Narcolepsy? (Excessive Uncontrollable Daytime Sleepiness)

Owens, J. Ritchie and A.


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These patients have difficulty with not only staying awake during the day but also with staying asleep during the night. It is also very common for patients with narcolepsy type 1 to experience sleep paralysis and hallucinations. On the other hand, patients with narcolepsy type 2 do not experience cataplexy, but also have difficulty with daytime wakefulness. Just as in narcolepsy type 1, it is also common for patients with narcolepsy type 2 to experience sleep paralysis and hallucinations.

Patients with idiopathic hypersomnia have difficulty with daytime wakefulness, and they do not experience cataplexy. Conversely, to narcolepsy type 1, patients with idiopathic hypersomnia do not have problems with staying asleep during the night and only sometimes experience sleep paralysis and hallucinations. They also commonly experience sleep drunkenness. The prevalence of narcolepsy type 1 is 0. Both narcolepsy and idiopathic hypersomnia usually first occur when patients are in their teens to 30s.

Patients with narcolepsy type 1 have low levels of hypocretin Hypocretin, also known as orexin, is a neurotransmitter that regulates alertness, mood, and appetite.

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One of the groups, headed by Dr. For now, the naming controversy continues — both camps are firmly entrenched in their terminology and neither will budge. Whatever its name, high levels of this neurotransmitter are associated with increased appetite, improved mood, and enhanced wakefulness. Low or nonexistent levels of hypocretin are found in the cerebrospinal fluid of people with type 1 narcolepsy.

These low hypocretin levels are probably due to both environmental exposure and inherited genetic factors. Getting an infection may also cause narcolepsy to develop. For example, narcolepsy became three times more common in China after an outbreak of the H1N1 flu virus. Although several studies have investigated factors that may contribute to the development of narcolepsy type 2 and idiopathic hypersomnia, it is currently unknown whether environmental exposures or genetic factors contribute to these disorders.

Three months of EDS symptoms are necessary for a diagnosis of all three central disorders of hypersomnolence.