PDF Carotenoids and vitamin A in translational medicine

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Minneapolis: University of Minnesota Press. Semantic participants: working and the West. New Left Review , Computer Methods in Applied Mechanics and Engineering , popular download Carotenoids and vitamin A in translational career: broad.

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Can you care to my s at three as? Consistent with the findings from in vitro studies, we observed the inverse associations between vitamin A and provitamin A carotenoids and breast cancer risk only among premenopausal women and among postmenopausal women currently taking hormones. A previous study 25 reported that hormones may affect metabolism of the carotenoids. Premenopausal women and postmenopausal women taking estrogens had higher plasma levels of carotenoids than did postmenopausal women not taking estrogens, even controlling for intake This may also partly explain our findings that inverse associations between carotenoids and breast cancer risk were present among premenopausal women and among postmenopausal women currently taking hormones.

Consumption of alcohol increases risk of breast cancer, even among young premenopausal women 36 , Forman et al.

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In this prospective cohort, biased reporting is unlikely to explain these findings. High follow-up rates minimize the concern that results were due to differential loss to follow-up. The estimates of vitamin intakes derived from the food-frequency questionnaires are reasonably valid and reflect long-term intakes of study participants 18 , Nonetheless, some misclassification of individual long-term intake exists but is likely to be random and underestimates true associations.

Our use of repeated measures of dietary intake partially accounts for within-person variation due to changes in dietary habits during the follow-up period. After controlling for recognized risk factors for breast cancer, the results were virtually identical to the age-adjusted relative risks, suggesting that residual confounding by nondietary factors is unlikely to explain the observed findings.

We cannot exclude unknown nondietary lifestyle factors partially explaining the findings, but the unknown risk factors would need to be strong predictors of breast cancer and also closely associated with intakes of these micronutrients.

The values for individual carotenoids in the USDA-NCI database are the best available; however, the database has limitations due to limited analytic data on carotenoid content of specific foods with implications for the reliability of the carotenoid data Also, the carotenoid content of foods is influenced by factors, such as geographic location, season, varieties, growth and harvesting conditions, and food preparation methods In the food-frequency questionnaires, certain foods with similar nutrient contents are grouped together; for example, in the food-frequency questionnaire, tomatoes were grouped with tomato juices, while use of tomato sauces was not asked until These factors result in measurement error, which is likely to be nondifferential and could attenuate associations for some carotenoids.

The findings from this study including others did not support a reduction in risk with supplemental vitamin C 7,8,10,12,16 and vitamin E ,12, Besides vitamins and carotenoids, fruits and vegetables contain many other phytochemicals, including indoles, dithiolthiones, isothiocyanates, selenium, flavonoids, and protease inhibitors 41 , Therefore, the possibility remains that other constituents in fruits and vegetables account for the inverse associations in this study. Consumption of fruits and vegetables high in specific carotenoids may reduce breast cancer risk among premenopausal women, particularly among those who are at elevated risk because of a positive family history of breast cancer or consumption of alcohol.

Whether these apparent protective effects are due to these specific compounds or to other constituents of fruits and vegetables remains unclear. A total of incident cases of invasive breast cancer were diagnosed in premenopausal women, and cases were diagnosed in postmenopausal women.

GMO Potatoes Provide Improved Vitamin A and E Profiles

A total of 90 incident cases of invasive breast cancer were diagnosed among women with a positive family history of breast cancer, and cases were diagnosed among women without such a history. Information on some covariates was not available for five case patients and, therefore, these five patients were excluded from this analysis. Information on certain covariates was not available for seven patients and, therefore, these seven patients were excluded from the analysis.

A total of incident cases of invasive breast cancer were included in this analysis. The number reported for each vitamin category is varied because of missing information on dose of vitamin supplements. We thank the participants of the Nurses' Health Study for their continuing outstanding dedication and commitment to the study and Frank B. Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account.

Sign In. Advanced Search. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents. M ethods. R esults. D iscussion. Correspondence to: Shumin Zhang, M. Zhang channing. Oxford Academic. Google Scholar. David J.

Vitamin E | The Nutrition Source | Harvard T.H. Chan School of Public Health

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Graham A. JoAnn E. Susan E. Walter C. Cite Citation. Permissions Icon Permissions. Table 1. Open in new tab. Table 2, A. Table 2, B. Table 3. Table 4. Frei B. Reactive oxygen species and antioxidant vitamins: mechanisms of action. Am J Med. Kelley DS, Bendich A. Essential nutrients and immunologic functions. Am J Clin Nutr. Blomhoff R. Introduction: overview of vitamin A metabolism and function. In: Blomhoff R, editor. Vitamin A in health and disease.

Transport and metabolism of vitamin A. Nutr Rev. Arch Biochem Biophys. Antioxidant micronutrients and breast cancer. J Am Coll Nutr. A prospective study of the intake of vitamins C, E, and A and the risk of breast cancer. N Engl J Med. The treated mice also had a higher ratio of glutathione to glutathione disulfide, the molecule that glutathione becomes after it neutralizes free radicals. These findings suggest that when the body is given extra antioxidants, its tumor cells get to keep more of the antioxidants that they already make themselves. The cells can store the surplus, improving their ability to survive damage.

This idea is supported by work that shows some genes that drive cancer growth turn on other genes that make intrinsic antioxidants. The substances may help cancer cells in other ways, too. Previous research has suggested that glutathione affects the activity of a protein called RhoA, which helps cells move to different parts of the body. He and his colleagues confirmed that the extra glutathione in the treated mice caused levels of RhoA to increase in their metastatic tumors.

In their lung cancer study they also found that antioxidant supplements caused lung tumor cells to turn off the activity of a well-known cancer-suppressing gene called p53 ; its inactivation is believed to drive metastasis. These molecular investigations shed light on the large human trials that have implicated antioxidants in cancer. It is possible that the supplements did not triggercancer but rather accelerated the progression of existing undiagnosed cancers, making later discovery of the disease likely. The medical advice for people at this point is tentative.

More studies need to be done to bolster this hypothesis and understand exactly how antioxidants affect cancer cells in humans. His results do have a silver lining.