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The authors address several of the major drug metabolizing systems, including the cytochrome P family, flavin-containing monooxygenases, glutathione, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low-molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy. The strategies detailed for transport phenomena cover the multidrug resistance proteins, the reduced folate carrier, the plasma membrane, and mitochondrial glutathione transporters, and can be applied to numerous other transport systems.

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Many chapters contain step-by-step methods for investigating metabolism and transport. Insightful and broad-ranging, Drug Metabolism and Transport: Molecular Methods and Mechanisms offers novice and experienced investigators alike a highly useful compendium of key strategies and approaches to successful research on drug metabolism and transport pathways.

1. Introduction

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Influence of Dietary Substances on Intestinal Drug Metabolism and Transport

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Drug Metabolism and Transport : Molecular Methods and Mechanisms

Ray, Martin Hoagland, Earl D. Kim, Kimberley J. Woodcroft, and Raymond F.

This book presents a collection of reviews on important topics in metabolism and transport. The editor has selected several of the major drug metabolizing systems, including the cytochrome P family, flavin-containing monooxtgenases, glutathione S-transferases, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present approaches to the study of signaling pathways in the regulation of drug metabolism enzymes and how modulation of these pathways can influence antiviral therapy.

Drug Metabolism and Transport : Lawrence H. Lash :

The transport chapters cover multidrug resistance proteins, the reduced folate carrier, and plasma membrane and mitochondrial glutatione transporters. Release Date: Binding: Hardback. Free Returns We hope you are delighted with everything you buy from us. However, if you are not, we will refund or replace your order up to 30 days after purchase. Terms and exclusions apply; find out more from our Returns and Refunds Policy.


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