Manual Clinical Aspects of Microdialysis

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Volume Issue 1 Jul in Journal of Neurosurgery. Article Information. Address reprint requests to: Peter J. Hutchinson, F.

The First 72 Hours of Brain Tissue Oxygenation Predicts Patient Outcome with Traumatic Brain Injury

Hutchinson dial. Keywords: microdialysis ; cerebral metabolism ; clinical examination Page Count: 37— View in gallery Photograph showing the triple-lumen cranial access device holding two microdialysis catheters and an ICP sensor in a demonstration skull. View in gallery Graphs depicting validation of the microdialysis technique, showing superimposed curves.

View in gallery Graphs showing substrate and metabolite concentrations obtained using microdialysis in a patient with a severe head injury and depicting the difference in substance recovery between a mm and a mm catheter. View in gallery Graphs showing microdialyzed glucose, lactate, pyruvate, and glutamate concentrations in a patient with head injury and demonstrating minimal differences between the use of catheters perfused with Ringer's solution and normal saline.

View in gallery Graphs depicting determination of the relative recovery for glucose by using a modification of the extrapolation-to-zero-flow method. View in gallery Graph showing results over time of glutamate analysis performed using the bedside analyzer filled diamonds compared with that performed using HPLC empty diamonds , demonstrating good correlation between values.

View raw image Close. Lancet — Editorial Anonymous : Microdialysis. Lancet : — , Editorial Anonymous: Microdialysis. Neurol Res —, false. J Neurochem — Benveniste H : Brain microdialysis.


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J Neurochem 52 : — , Benveniste H: Brain microdialysis. J Neurochem —, false. J Neurosurg —, false. Arch Int Pharmacodyn Ther 9—21, false. Lancet —, false. J Physiol —, false. Acta Neurochir Suppl 37—39, false. J Intern Med —, false. Epilepsy Res 9: 32—43, false. Br J Neurosurg 87P, false. J Neurosci Methods — Jacobson I , Sandberg M , Hamberger A : Mass transfer in brain dialysis devices—a new method for the estimation of extracellular amino acids concentration.

J Neurosci Methods 15 : — , Jacobson I, Sandberg M, Hamberger A: Mass transfer in brain dialysis devices—a new method for the estimation of extracellular amino acids concentration. J Neurosci Methods —, false. J Neurosci Methods — Kehr J : A survey on quantitative microdialysis: theoretical models and practical implications. J Neurosci Methods 48 : — , Kehr J: A survey on quantitative microdialysis: theoretical models and practical implications. La Laguna: University of La Laguna, , pp — false.

Am J Physiol E—E, false. Anal Chem —, false. Acta Neurochir Suppl 48—52, false. J Neurosurg 1—10 Menzel M , Doppenberg EM , Zauner A , et al : Increased inspired oxygen concentration as a factor in improved brain tissue oxygenation and tissue lactate levels after severe human head injury. J Neurosurg 91 : 1 — 10 , Menzel M, Doppenberg EM, Zauner A, et al: Increased inspired oxygen concentration as a factor in improved brain tissue oxygenation and tissue lactate levels after severe human head injury.

J Neurosurg 1—10, false. Life Sci —, false. J Neurochem — Moghaddam B , Bunney BS : Ionic composition of microdialysis perfusing solution alters the pharmacological responsiveness and basal outflow of striatal dopamine. J Neurochem 53 : — , Moghaddam B, Bunney BS: Ionic composition of microdialysis perfusing solution alters the pharmacological responsiveness and basal outflow of striatal dopamine. J Physiol Lond — Nicholson C , Phillips JM : Ion diffusion modified by tortuosity and volume fraction in the extracellular microenvironment of the rat cerebellum.

J Physiol Lond : — , Nicholson C, Phillips JM: Ion diffusion modified by tortuosity and volume fraction in the extracellular microenvironment of the rat cerebellum. Ann NY Acad Sci 55—71, false. J Neurosurg 72—80 Persson L , Hillered L : Chemical monitoring of neurosurgical intensive care patients using intracerebral microdialysis. J Neurosurg 76 : 72 — 80 , Persson L, Hillered L: Chemical monitoring of neurosurgical intensive care patients using intracerebral microdialysis.

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